Selective inhibition of histone deacetylase 3 by novel hydrazide based small molecules as therapeutic intervention for the treatment of cancer
Sravani Pulya, Tarun Patel, Milan Paul, Nilanjan Adhikari, Suvankar Banerjee, Ganesh Routholla, Swati Biswas, Tarun Jha, Balaram Ghosh
Topics & Concepts
ChemistryHDAC3Histone deacetylaseHistone deacetylase inhibitorAcetylationVorinostatCell growthApoptosisCancer researchCell cycleDownregulation and upregulationCytotoxicityPharmacologyBiochemistryHistoneIn vitroBiologyGeneHistone Deacetylase Inhibitors ResearchProtein Degradation and InhibitorsPeptidase Inhibition and Analysis