Straightforward Access to Thiocyanates via Dealkylative Cyanation of Sulfoxides
Uroš Todorović, Immo Klose, Nuno Maulide
Abstract
Thiocyanates, versatile building blocks in organic synthesis, are shown to be easily accessible via an interrupted Pummerer reaction of sulfoxides. This facile dealkylative functionalization proceeds under mild conditions through electrophilic activation of the sulfoxide partner. The resulting thiocyanate itself can serve as a handle for diversification in a straightforward one-pot procedure.
Topics & Concepts
ChemistryElectrophileSulfoxideCyanationCombinatorial chemistryThiocyanateSurface modificationOrganic chemistryCatalysisPhysical chemistrySulfur-Based Synthesis TechniquesChemical Synthesis and ReactionsCatalytic C–H Functionalization Methods