Triptolide and atorvastatin synergistically promote hepatotoxicity in cultured hepatocytes and female Sprague-Dawley rats by inhibiting pregnane X receptor-mediated transcriptional activation of CYP3A4
Nan Zheng, Aili Wei, Tong Wu, Long Long, Haiying Yang, Hua Li, Lili Wang
Topics & Concepts
TriptolidePregnane X receptorCYP3A4Tripterygium wilfordiiPharmacologyAtorvastatinDownregulation and upregulationLiver injuryChemistryApoptosisBiologyNuclear receptorTranscription factorCytochrome P450MedicineEnzymeBiochemistryGenePathologyAlternative medicineNatural Compounds in Disease TreatmentChemotherapy-induced organ toxicity mitigationAcute Myeloid Leukemia Research