Abnormal development of auditory responses in the inferior colliculus of a mouse model of Fragile X Syndrome
Anna O. Nguyen, Devin K. Binder, Iryna M. Ethell, Khaleel A. Razak
Abstract
Autism spectrum disorders (ASD) are commonly associated with sensory sensitivity issues, but the underlying mechanisms are unclear. This study presents novel evidence for neural correlates of auditory hypersensitivity in the developing inferior colliculus (IC) in the Fmr1 knockout (KO) mouse, a mouse model of Fragile X Syndrome (FXS), a leading genetic cause of ASD. Responses begin to show genotype differences between postnatal days 14 and 21, suggesting an early developmental treatment window.
Topics & Concepts
Inferior colliculusFragile X syndromeNeuroscienceFMR1Autism spectrum disorderAutismSensory systemPsychologyKnockout mouseSensory processingAudiologyBiologyFragile xMedicineDevelopmental psychologyGeneticsPsychiatryNucleusGeneReceptorGenetics and Neurodevelopmental DisordersAutism Spectrum Disorder ResearchRNA regulation and disease