Emetine, a potent alkaloid for the treatment of SARS-CoV-2 targeting papain-like protease and non-structural proteins: pharmacokinetics, molecular docking and dynamic studies
Mejdi Snoussi, Alaeddine Redissi, Amor Mosbah, Vincenzo De Feo, Mohd Adnan, Kaïss Aouadi, Mousa Alreshidi, Mitesh Patel, Adel Kadri, Emira Noumi
Abstract
Å. Overall, supported by the powerful and good pharmacokinetic data of Emetine, our findings with clinical trials may be helpful to confirm that Emetine could be promoted in the prevention and eradication of COVID-19 by reducing the severity in the infected persons and therefore can open possible new strategies for drug repositioning. Communicated by Ramaswamy H. Sarma.
Topics & Concepts
EmetineDocking (animal)ChemistryStereochemistryMolecular dynamicsDimerMolecular mechanicsLigand (biochemistry)MoleReceptorBiochemistryBiologyPharmacologyComputational chemistryOrganic chemistryMedicineNursingComputational Drug Discovery MethodsCancer therapeutics and mechanismsSynthesis and Biological Evaluation