Toll-like receptor 4: A potential therapeutic target for multiple human diseases
Jinrui Wei, Yan Zhang, H. Li, Fuquan Wang, Shanglong Yao
Abstract
The immune response plays a pivotal role in the pathogenesis of diseases. Toll-like receptor 4 (TLR4), as an intrinsic immune receptor, exhibits widespread in vivo expression and its dysregulation significantly contributes to the onset of various diseases, encompassing cardiovascular disorders, neoplastic conditions, and inflammatory ailments. This comprehensive review centers on elucidating the architectural and distributive characteristics of TLR4, its conventional signaling pathways, and its mode of action in diverse disease contexts. Ultimately, this review aims to propose novel avenues and therapeutic targets for clinical intervention.
Topics & Concepts
TLR4Toll-like receptorReceptorImmune systemDiseaseTLR7PathogenesisSignal transductionTollImmunologyMedicineNeuroscienceBiologyBioinformaticsInnate immune systemGeneticsInternal medicineImmune Response and InflammationImmune cells in cancerAsthma and respiratory diseases