Iron-Catalyzed Borylation of Aryl Ethers via Cleavage of C–O Bonds
Xiaoqin Zeng, Yuxuan Zhang, Zhengli Liu, Shasha Geng, Yun He, Feng Zhang
Abstract
Herein, we report the iron-catalyzed borylation of aryl ethers and aryl amines via cleavage of C-O and C-N bonds. This protocol does not require the use of Grignard reagents and displays a broad substrate scope, which allows the late-stage borylation. It also provides facile access to multisubstituted arenes through C-H functionalization using 2-pyridyloxy as the directing group.
Topics & Concepts
BorylationChemistryArylCatalysisCleavage (geology)ReagentCombinatorial chemistryBond cleavageMedicinal chemistrySubstrate (aquarium)Functional groupOrganic chemistryOceanographyEngineeringGeologyAlkylPolymerFracture (geology)Geotechnical engineeringCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling ReactionsOrganoboron and organosilicon chemistry