Metformin alleviates cisplatin-induced ototoxicity by autophagy induction possibly via the AMPK/FOXO3a pathway
Zhengrong Liang, Tao Zhang, Ting Zhan, Gui Cheng, Weijian Zhang, Haiying Jia, Haidi Yang
Abstract
Cisplatin is an antitumor drug that is widely used for the treatment of various solid tumors. Up to now, there have been no clear and effective measures to prevent cisplatin-induced ototoxicity in clinical use. We investigated the protective effect of metformin on cisplatin ototoxicity in vitro and in vivo. Our findings indicate that metformin alleviates cisplatin-induced ototoxicity possibly through AMPK/FOXO3a-mediated autophagy machinery. This study underpins further researches on the prevention and treatment of cisplatin ototoxicity.
Topics & Concepts
OtotoxicityMetforminCisplatinAutophagyAMPKPharmacologyIn vivoMedicineChemistryApoptosisDiabetes mellitusInternal medicineEndocrinologyChemotherapyBiologyBiochemistryEnzymeProtein kinase ABiotechnologyHearing, Cochlea, Tinnitus, Genetics