Enteroendocrine cells: the gatekeepers of microbiome-gut-brain communication
Esmée Grundeken, Sahar El Aidy
Abstract
Enteroendocrine cells (EECs) are gut epithelial hormone-secreting cells, influenced by diet and the microbiome. EECs regulate local gastrointestinal functions and systemic signalling, including communication with the brain, while being linked to various diseases, yet their systemic integration remains underexplored. This review examines the metabolic and systemic roles of EECs, focusing on interactions with dietary components, the microbiome, and disease pathways, while identifying key research gaps to guide future studies.
Topics & Concepts
MicrobiomeEnteroendocrine cellGut microbiomeBiologyNeuroscienceDiseaseGut–brain axisEndocrine systemHormoneBioinformaticsMedicinePathologyEndocrinologyGut microbiota and healthGastrointestinal motility and disordersInfant Health and Development