Delivery, structure, and function of bacterial genotoxins
Liaoqi Du, Jeongmin Song
Abstract
Typhi, as well as small polyketide-peptides named colibactin that causes the DNA interstrand cross-linking and subsequent DSBs is the most well-characterized bacterial genotoxins. Using these three examples, this review discusses the mechanisms by which these toxins deliver themselves into the nucleus of the target host cells and exert their genotoxic functions at the structural and functional levels.
Topics & Concepts
BiologyCytolethal distending toxinPathogenDNA damageDNAMicrobiologySalmonellaVirulenceBacterial cell structureFunction (biology)BacteriaToxinCell biologyGeneticsMicrobial toxinsGeneBacterial Genetics and BiotechnologyBacteriophages and microbial interactionsBacillus and Francisella bacterial research