Host Defense Mechanisms Induce Genome Instability Leading to Rapid Evolution in an Opportunistic Fungal Pathogen
Amanda Smith, Levi T. Morran, Meleah A. Hickman
Abstract
The ability to generate genetic variation facilitates rapid adaptation in stressful environments. The opportunistic fungal pathogen Candida albicans frequently undergoes large-scale genomic changes, including aneuploidy and loss of heterozygosity (LOH), following exposure to host environments.
Topics & Concepts
BiologyLoss of heterozygosityGenome instabilityPathogenOpportunistic pathogenCandida albicansFungal pathogenHost (biology)Adaptation (eye)GeneticsHost adaptationGenomeAneuploidyMicrobiologyVirulenceGeneAlleleDNA damageDNAChromosomeNeuroscienceAntifungal resistance and susceptibilityFungal Infections and StudiesInfectious Diseases and Mycology