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An enhancer-based gene-therapy strategy for spatiotemporal control of cargoes during tissue repair

Ruorong Yan, Valentina Cigliola, Kelsey A Oonk, Zachary Petrover, Sophia DeLuca, David Wolfson, Andrew M. Vekstein, Michelle A. Mendiola, Garth Devlin, Muath Bishawi, Matthew Gemberling, Tanvi Sinha, Michelle A. Sargent, Allen J. York, Avraham Shakked, Paige DeBenedittis, David C. Wendell, Jianhong Ou, Junsu Kang, Joseph Goldman, Gurpreet S. Baht, Ravi Karra, Adam Williams, Dawn E. Bowles, Aravind Asokan, Eldad Tzahor, Charles A. Gersbach, Jeffery D. Molkentin, Nenad Bursac, Brian L. Black, Kenneth D. Poss

2022Cell stem cell67 citationsDOIOpen Access PDF

Topics & Concepts

BiologyEnhancerZebrafishGenome editingRegeneration (biology)Cas9CRISPRGenetic enhancementComputational biologyCell biologyGeneGene expressionBioinformaticsGeneticsCongenital heart defects researchCRISPR and Genetic Engineeringinterferon and immune responses