Parkin-mediated mitophagy is a potential treatment for oxaliplatin-induced peripheral neuropathy
Guoqing Zhao, Te Zhang, Jiannan Li, Longyun Li, Peng Chen, Chun‐Lu Zhang, Kai Li, Cancan Cui
Abstract
This article discusses the effects and mechanisms of Parkin-mediated mitophagy in oxaliplatin-induced peripheral nerve pain (OIPNP) from both in vivo and in vitro. We believe that our study makes a significant contribution to the literature because OIPNP has always been the focus of clinical medicine, and mitochondrial quality regulation mechanisms especially Parkin-mediated mitophagy, have been deeply studied in recent years. We use a variety of molecular biological techniques and animal experiments to support our argument.
Topics & Concepts
MitophagyParkinPeripheral neuropathyOxaliplatinPeripheralMedicineNeuroscienceBiologyInternal medicineParkinson's diseaseEndocrinologyGeneticsApoptosisCancerDiabetes mellitusAutophagyDiseaseColorectal cancerCancer Treatment and PharmacologySphingolipid Metabolism and SignalingGlycogen Storage Diseases and Myoclonus