Design, synthesis, and biological evaluation of novel pyrido-dipyrimidines as dual topoisomerase II/FLT3 inhibitors in leukemia cells
Mohamed A. Abdelgawad, Fatma El Zahraa Ammar Mohamed, Phoebe F. Lamie, Syed Nasir Abbas Bukhari, Mohammad M. Al‐Sanea, Arafa Musa, Mohammed Elmowafy, AbdElAziz A. Nayl, Ahmed Karam Farag, Sameeha M. Ali, Mohamed E. Shaker, Hany A. Omar, Mohammed K. Abdelhameid, Manal M. Kandeel
Topics & Concepts
AmsacrineTopoisomeraseChemistryApoptosisAnnexinLeukemiaCell cultureIn vitroHL60EnzymeMolecular biologyBiochemistryBiologyImmunologyGeneticsCancer therapeutics and mechanismsLung Cancer Research StudiesAcute Lymphoblastic Leukemia research