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Systemic rewiring of dendritic cells by melanoma-secreted midkine impairs immune surveillance and response to immune checkpoint blockade

Xavier Catena, Marta Contreras-Alcalde, Naiara Juan-Larrea, Daniela Cerezo‐Wallis, Tonantzin G. Calvo, Cynthia Mucientes, David Olmeda, Javier Suárez, Sergio Oterino-Sogo, Lola Martínez, Diego Megı́as, David Sancho, Cristina Tejedo, Susana Frago, Diana Dudziak, Athanasios Seretis, Patrizia Stoitzner, Marı́a S. Soengas

2025Nature Cancer15 citationsDOI

Topics & Concepts

MidkineBlockadeImmune checkpointImmune systemMelanomaCancer researchImmunologyMedicineBiologyImmunotherapyReceptorGrowth factorInternal medicineImmunotherapy and Immune ResponsesChemokine receptors and signalingT-cell and B-cell Immunology
Systemic rewiring of dendritic cells by melanoma-secreted midkine impairs immune surveillance and response to immune checkpoint blockade | Litcius