Imaging Acute Metabolic Changes in Patients with Mild Traumatic Brain Injury Using Hyperpolarized [1-13C]Pyruvate
Edward P. Hackett, Marco C. Pinho, Crystal Harrison, Galen D. Reed, Jeff Liticker, Jaffar Ali Raza, Ronald G. Hall, Craig R. Malloy, Surendra Barshikar, Christopher J. Madden, Jae Mo Park
Abstract
) production, and one showed hyperintense lactate production at the injured sites. This study reports the feasibility of imaging altered metabolism using hyperpolarized pyruvate in patients with TBI, demonstrating the translatability and sensitivity of the technology to cerebral metabolic changes after mild TBI.
Topics & Concepts
Traumatic brain injuryNeuroimagingMedicineChemistryPsychiatryAdvanced NMR Techniques and ApplicationsAtomic and Subatomic Physics ResearchAdvanced MRI Techniques and Applications