Copper-Catalyzed Cyclization of <i>N</i>-Propargyl Ynamides with Borane Adducts through B–H Bond Insertion
Guang‐Yu Zhu, Tong‐Yi Zhai, Xiao Li, Chong‐Yang Shi, Xin‐Qi Zhu, Long‐Wu Ye
Abstract
-propargyl ynamides with borane adducts through B-H bond insertion has been developed. A series of valuable organoboron compounds are constructed in generally good yields with a wide substrate scope and good functional group tolerance under mild reaction conditions. Importantly, this protocol via vinyl cation intermediates constitutes a novel way of B-H bond insertion.
Topics & Concepts
ChemistryPropargylAdductBoraneCatalysisMedicinal chemistryFunctional groupInsertion reactionSubstrate (aquarium)Triple bondCombinatorial chemistryStereochemistryDouble bondOrganic chemistryOceanographyGeologyPolymerCatalytic Alkyne ReactionsCyclopropane Reaction MechanismsCatalytic Cross-Coupling Reactions