Disturbed flow-induced FAK K152 SUMOylation initiates the formation of pro-inflammation positive feedback loop by inducing reactive oxygen species production in endothelial cells
Loka Reddy Velatooru, Rei Abe, Masaki Imanishi, Young Jin Gi, Kyung Ae Ko, Kyung‐Sun Heo, Keigi Fujiwara, Nhat-Tu Le, Sivareddy Kotla
Topics & Concepts
SUMO proteinReactive oxygen speciesCell biologySenescenceEndothelial activationPhosphorylationNADPH oxidaseChemistryEndothelial dysfunctionFocal adhesionBiologyInflammationBiochemistryImmunologyEndocrinologyUbiquitinGeneNeutrophil, Myeloperoxidase and Oxidative MechanismsCell Adhesion Molecules ResearchProtease and Inhibitor Mechanisms