A micro-flow rapid dual activation approach for urethane-protected α-amino acid <i>N</i>-carboxyanhydride synthesis
Ren Okabe, Naoto Sugisawa, Shinichiro Fuse
Abstract
generated acylpyridinium cation was highly active and less prone to causing undesired decomposition compared with the acylammonium cation examined in this study. Thus, even at a very low concentration, the acylpyridinium cation facilitated the desired coupling reaction.
Topics & Concepts
Dual (grammatical number)Amino acidChemistryFlow (mathematics)Combinatorial chemistryBiochemistryPhysicsMechanicsLiteratureArtInnovative Microfluidic and Catalytic Techniques InnovationChemical Synthesis and AnalysisMicrofluidic and Capillary Electrophoresis Applications