Molecularly imprinted polymers-based biosensors for gynecological diagnostics and monitoring
Faezeh Ghorbanizamani, Hichem Moulahoum, Figen Zihnioğlu, Suna Tımur
Abstract
• Overview of the latest techniques for MIP synthesis and characterization. • Understanding gynecological diseases, biomarkers, and current diagnostic methods. • Advances in MIP-based biosensors for gynecological diagnostics. • Available MIP biosensors for gynecological conditions diagnosis. • Challenges in clinical application of MIP technology. Molecularly Imprinted Polymers (MIPs) offer promising advancements in gynecological diagnostics due to their high selectivity, stability, and cost-effectiveness. This review explores the application of MIP-based biosensors in detecting biomarkers for gynecological cancer, infections, and hormonal monitoring. Despite significant progress in MIP technology, its integration into clinical gynecology remains limited. The review provides a deep dive into the synthesis and characterization process of MIPs, current diagnostic methods, and the potential of emerging diagnostic approaches such as microfluidics and nanotechnology. Then, an overview of the various conditions, diseases, and potential biomarkers is explored. Emphasizing the importance of women's health, the review analyzes the latest research in MIP-based biosensing of gynecological conditions and calls for increased research and development to bridge the gap between laboratory innovation and clinical application. The goal is to enhance early detection, improve patient outcomes, and reduce healthcare costs. This advancement is essential for better disease management and personalized treatment in gynecology.