Photoinduced PhI(OAc)<sub>2</sub>-Mediated Cross-Dehydrogenative Heteroarylation of Aldehydes
Lusina Mantry, Parthasarathy Gandeepan
Abstract
Direct acylation of heteroarenes with aldehydes has been established through a photoinduced hypervalent iodine-mediated cross-dehydrogenative coupling reaction. The reaction proceeds through the in situ generation of nucleophilic acyl radicals from aldehydes via acyl C-H hydrogen atom transfer (HAT), followed by a Minisci-type reaction with heteroarenes. The developed reaction system proved to be suitable for cross-coupling a diverse range of heterocycles and aldehydes.
Topics & Concepts
ChemistryPhotochemistryBusinessCatalytic C–H Functionalization MethodsRadical Photochemical ReactionsSulfur-Based Synthesis Techniques