Addition of sulfonylphthalides to <i>para</i>-quinone methides: Selective 1,6-additions and oxidative annulations
Kavyashree Kuppayya Gond, Mahagundappa Rachappa Maddani
Abstract
an unprecedented oxidative annulation pathway. The present work highlights a wide variety of substrates, good yields, shorter reaction time and ambient reaction conditions. Furthermore, a few addition products were transformed into functionalized heterocyclic molecules. Additionally, the scale-up experiment suggests the practical feasibility of preparing isochroman-1,4-diones in higher-scale reactions.
Topics & Concepts
ChemistryQuinoneOxidative phosphorylationMoleculeCombinatorial chemistryAnnulationOrganic chemistryCatalysisBiochemistrySynthesis of Indole DerivativesChemical Synthesis and ReactionsBioactive Compounds and Antitumor Agents