Enantio‐ and Diastereoselective Synthesis of Homopropargyl Amines by Copper‐Catalyzed Coupling of Imines, 1,3‐Enynes, and Diborons
Srimanta Manna, Quentin Dherbassy, Gregory J. P. Perry, David J. Procter
Abstract
Abstract An efficient, enantio‐ and diastereoselective, copper‐catalyzed coupling of imines, 1,3‐enynes, and diborons is reported. The process shows broad substrate scope and delivers complex, chiral homopropargyl amines; useful building blocks on the way to biologically‐relevant compounds. In particular, functionalized homopropargyl amines bearing up to three contiguous stereocenters can be prepared in a single step.
Topics & Concepts
StereocenterCombinatorial chemistrySubstrate (aquarium)CatalysisChemistryCopperCoupling (piping)Scope (computer science)Enantioselective synthesisOrganic chemistryComputer scienceMaterials scienceProgramming languageMetallurgyGeologyOceanographyOrganoboron and organosilicon chemistrySynthetic Organic Chemistry MethodsCatalytic Cross-Coupling Reactions