Copper-catalyzed asymmetric cyclization of alkenyl diynes: method development and new mechanistic insights
Xin‐Qi Zhu, Pan Hong, Yan-Xin Zheng, Ying-Ying Zhen, Feng‐Lin Hong, Xin Lü, Long‐Wu Ye
Abstract
remote-stereocontrol is proposed, thus providing new mechanistic insight into the copper-catalyzed asymmetric diyne cyclization and representing a new chiral control pattern in asymmetric catalysis based on remote-stereocontrol and vinyl cations. This method enables the practical and atom-economical construction of an array of valuable chiral polycyclic-pyrroles in high yields and enantioselectivities.
Topics & Concepts
CatalysisCopperChemistrySurface modificationCombinatorial chemistryEnantioselective synthesisOrganic chemistryPhysical chemistryCatalytic Alkyne ReactionsCatalytic C–H Functionalization MethodsCyclopropane Reaction Mechanisms