Transition metal-free functionalization of 2-oxindoles<i>via</i>sequential aldol and reductive aldol reactions using rongalite as a C1 reagent
Sivaparwathi Golla, Swathi Jalagam, Soumya Poshala, Hari Prasad Kokatla
Abstract
Rongalite induced transition metal and hydride-free reductive aldol reaction is developed for 3-methylindoline-2-ones and 3-(hydroxymethyl)-3-methylindolin-2-ones from 2-oxindoles. Here, Rongalite plays a key role of being a reductant and C1 source.
Topics & Concepts
Aldol reactionReagentChemistryTransition metalHydrideAldol condensationSurface modificationCombinatorial chemistryOrganic chemistryMetalCatalysisPhysical chemistryAlkaloids: synthesis and pharmacologyAsymmetric Synthesis and CatalysisChemical synthesis and alkaloids