Tumor Microenvironment-Responsive MnO<sub><i>x</i></sub>-Mesoporous Carbon Nanoparticles for Enhanced Chemodynamic Synergistic Antitumor Therapy
Rongrong Zhang, Tingting Wang, Haiyu Shen, Xue Zhou, Qinghe Han, Lu Li, Lingyu Zhang, Chungang Wang, Xiangting Dong
Abstract
Developing nanomedicines with simultaneous diagnosis and treatment functions is a promising therapeutic strategy for cancer therapy. Herein, multifunctional manganese oxide-mesoporous carbon nanoparticles (MnO x -MCN NPs) were designed for magnetic resonance imaging (MRI)-guided chemotherapy, photothermal therapy (PTT), and chemodynamic therapy (CDT). The excellent photothermal conversion efficiency (44.2%) and outstanding fenton-like catalytic activity endowed MnO x -MCN NPs with a PTT/CDT synergistic therapy. Furthermore, with their unique mesoporous structure, MnO x -MCN NPs can also act as a drug delivery carrier for encapsulating chemotherapy agent doxorubicin (DOX). The mild acid tumor microenvironment (TME) and near-infrared (NIR) heat induced the release of DOX. In addition, the NIR laser enhanced the CDT efficiency of MnO x -MCN NPs, thus generating a synergistic chemotherapy/PTT/CDT effect. Extracellular experiments demonstrated that the heat generated by laser irradiation of MnO x -MCN NPs could encourage the generation of • OH. More importantly, MnO x -MCN NPs displayed a superior synergistic anticancer efficiency both in vitro and in vivo. Such elaborately synthesized nanomaterial provides a paradigm for the design of other multifunction nanoagents.