TNF-α-producing macrophages determine subtype identity and prognosis via AP1 enhancer reprogramming in pancreatic cancer
Mengyu Tu, Lukas Klein, Elisa Espinet, Theodoros Georgomanolis, Florian Wegwitz, Xiaojuan Li, Laura Urbach, Adi Danieli‐Mackay, Stefan Küffer, Kamil Bojarczuk, Athanasia Mizi, Ufuk Günesdogan, Bjoern Chapuy, Zuguang Gu, Albrecht Neeße, Uday Kishore, Philipp Ströbel, Elisabeth Heßmann, Stephan A. Hahn, Andreas Trumpp, Argyris Papantonis, Volker Ellenrieder, Shiv K. Singh
Topics & Concepts
Cancer researchBiologyTumor necrosis factor alphaStromal cellAP-1 transcription factorReprogrammingImmune systemTumor microenvironmentImmunologyTranscription factorCellGeneticsGenePancreatic and Hepatic Oncology ResearchEpigenetics and DNA MethylationPhagocytosis and Immune Regulation