<i>N</i> -Heterocyclic carbene-catalyzed enantioselective (dynamic) kinetic resolution for the assembly of inherently chiral macrocycles
Zhipeng Li, Jingyang Zhang, Wanmeng Zhu, Tianyi Wang, Yefeng Tang, Jian Wang
Abstract
a dynamic kinetic resolution (DKR) or kinetic resolution (KR) process, enabling the conversion of racemic substrates into inherently chiral heterocalixaromatics with good to high yields and high to excellent enantioselectivities. DFT calculations were carried out to clarify the chirality control in the related DKR process.
Topics & Concepts
Kinetic resolutionEnantioselective synthesisCarbeneCatalysisChemistryCombinatorial chemistryKinetic energyStereochemistryComputational chemistryOrganic chemistryPhysicsQuantum mechanicsN-Heterocyclic Carbenes in Organic and Inorganic ChemistrySynthetic Organic Chemistry MethodsCoordination Chemistry and Organometallics