Multimodal antibacterial potency of newly designed and synthesized Schiff's/Mannich based coumarin derivatives: potential inhibitors of bacterial DNA gyrase and biofilm production
Kakarla Pakeeraiah, Pragyan Paramita Swain, Alaka Sahoo, Preetesh Kumar Panda, Monalisa Mahapatra, Suvadeep Mal, Rajesh Kumar Sahoo, Pratap Kumar Sahu, Sudhir Kumar Paidesetty
Abstract
assessment suggested that multimodal antibacterial derivatives 5d and 5f strongly inhibit both bacterial DNA gyrase and biofilm formation of drug-resistant pathogens, suggesting their potency in mainstream antibacterial therapy.
Topics & Concepts
DNA gyraseCoumarinChemistryPotencyAntibacterial activityCombinatorial chemistryBiofilmMultiple drug resistanceMannich reactionEscherichia coliBacteriaBiochemistryOrganic chemistryAntibioticsBiologyIn vitroGeneCatalysisGeneticsSynthesis and biological activitySulfur-Based Synthesis TechniquesPhenothiazines and Benzothiazines Synthesis and Activities