Design, synthesis, and biological evaluation of 2,4-diamino pyrimidine derivatives as potent FAK inhibitors with anti-cancer and anti-angiogenesis activities
Shan Wang, Rong‐Hong Zhang, Hong Zhang, Yuchan Wang, Dan Yang, Yong‐Long Zhao, Guoyi Yan, Guo‐Bo Xu, Huan-Yu Guan, Yanhua Zhou, Dongbing Cui, Ting Liu, Yongjun Li, Shang‐Gao Liao, Meng Zhou
Topics & Concepts
AngiogenesisChemistryFocal adhesionApoptosisProtein kinase BCell cycleCancer researchPI3K/AKT/mTOR pathwayKinaseFlow cytometryCancer cellCyclin D1CancerPharmacologyBiochemistryMolecular biologyCellBiologyInternal medicineMedicineCell Adhesion Molecules ResearchUbiquitin and proteasome pathwaysCell death mechanisms and regulation