Characterization and Antifungal Activity of Chlorhexidine:β-cyclodextrin Inclusion Complexes
Amanda Cristina Schoeffel, Francine Sumie Morikava, Amanda Migliorini Urban, Andressa Novatski, Gustavo Simão Moraes, Graciette Matioli, Priscileila Colerato Ferrari, Karin Hermana Neppelenbroek, Paulo Vítor Farago, Vanessa Migliorini Urban
Abstract
Aim: This study aimed to develop, characterize and analyze the antifungal activity of chlorhexidine:β-cyclodextrin inclusion complexes (Chx:βCD). Materials & methods: Chx:βCD were characterized by physicochemical techniques and the susceptibility of nine Candida strains was assessed. The inhibition of Candida albicans biofilm growth was evaluated in a denture material modified with the incorporation of Chx:βCD. Results: Chx was better complexed in 1:2 molar ratio by freeze-drying. Chx:βCD presented antifungal activity against all Candida strains. When incorporated into the denture material, Chx:βCD showed better antifungal activity, as it required about 7.5% of Chx concentration compared with the raw Chx for 14 days. Conclusion: The improved characteristics of Chx:βCD can result in new formulations to treat oral candidiasis and denture stomatitis.