Rational design of new multitarget histamine H3 receptor ligands as potential candidates for treatment of Alzheimer’s disease
Dorota Łażewska, Marek Bajda, Maria Kaleta, Paula Zaręba, Agata Doroż-Płonka, Agata Siwek, Alaa Alachkar, Szczepan Mogilski, Ali Saad, Kamil Kuder, Agnieszka Olejarz‐Maciej, Justyna Godyń, Dorota Stary, Sylwia Sudoł, Małgorzata Więcek, Gniewomir Latacz, Maria Walczak, Jadwiga Handzlik, Bassem Sadek, Barbara Malawska, Katarzyna Kieć‐Kononowicz
Topics & Concepts
ChemistryButyrylcholinesteraseAcetylcholinesteraseIC50Docking (animal)PharmacophoreIn vivoCholinesteraseHistamineHistamine H3 receptorStereochemistryInhibitory postsynaptic potentialPharmacologyIn vitroEnzymeReceptorCombinatorial chemistryBiochemistryAchéAntagonistBiotechnologyNursingMedicineBiologyNeuroscienceCholinesterase and Neurodegenerative DiseasesComputational Drug Discovery MethodsPhenothiazines and Benzothiazines Synthesis and Activities