Diastereoselective synthesis of atropisomeric pyrazolyl pyrrolo[3,4-<i>d</i>]isoxazolidines <i>via</i> pyrazolyl nitrone cycloaddition to facially divergent maleimides: intensive NMR and DFT studies
Awаd I. Said, Talaat I. El‐Emary
Abstract
Diastereoselective pyrazole-based atropisomeric cycloadducts were formed by cycloaddition of a pyrazole-based nitrone and maleimides with restricted rotation around C–N bond caused by bulk <italic>ortho</italic> substitution.
Topics & Concepts
NitroneCycloadditionAtropisomerChemistryStereochemistryOrganic chemistryCatalysisAxial and Atropisomeric Chirality SynthesisMolecular spectroscopy and chiralityAsymmetric Synthesis and Catalysis