Shedding Light on Extracellular Vesicle Biogenesis and Bioengineering
Fei Teng, Martin Fussenegger
Abstract
Extracellular vesicles (EVs) are biocompatible, nano-sized secreted vesicles containing many types of biomolecules, including proteins, RNAs, DNAs, lipids, and metabolites. Their low immunogenicity and ability to functionally modify recipient cells by transferring diverse bioactive constituents make them an excellent candidate for a next-generation drug delivery system. Here, the recent advances in EV biology and emerging strategies of EV bioengineering are summarized, and the prospects for clinical translation of bioengineered EVs and the challenges to be overcome are discussed.
Topics & Concepts
Extracellular vesiclesExtracellular vesicleBiogenesisImmunogenicityVesicleBiocompatible materialCell biologyDrug deliveryNanotechnologyMicrovesiclesTranslation (biology)ChemistryBiologyComputational biologyBiochemistryMaterials scienceImmune systemMedicineImmunologyGeneMessenger RNAMembranemicroRNABiomedical engineeringExtracellular vesicles in diseaseMicroRNA in disease regulationRNA Interference and Gene Delivery