Angiography-derived radial wall strain predicts coronary lesion progression in non-culprit intermediate stenosis.
Zhiqiang Wang, Bo Xu, Chunming Li, Changdong Guan, Yue Chang, Lihua Xie, Su Zhang, Jiayue Huang, Patrick W. Serruys, William Wijns, Lianglong Chen, Shengxian Tu
Abstract
BACKGROUND: Intermediate coronary lesions (ICLs) are highly prevalent but ported mixed prognosis. Radial strain has been associated with plaque vulnerability, yet its role in predicting lesion progression is largely unknown. The purpose of this study was to determine the predictive value of angiography-derived radial wall strain (RWS) for progression of untreated non-culprit ICLs. METHODS: analysis was conducted in a study cohort including 603 consecutive patients with 808 ICLs identified at index procedure with angiographic follow-up of up to two years. RWS analysis was performed on selected angiographic frames with minimal foreshortening and vessel overlap. Lesion progression was defined as ≥ 20% increase in percent diameter stenosis. RESULTS: < 0.001). CONCLUSIONS: Assessment of RWS from coronary angiography is feasible and provides independent prognostic value in patients with untreated ICLs.