Highlights in the fight against COVID-19: does autophagy play a role in SARS-CoV-2 infection?
Elizabeth Delorme‐Axford, Daniel J. Klionsky
Abstract
: ACE2, angiotensin converting enzyme II; βCoV, betacoronavirus; COVID-19, Coronavirus Disease 2019; CQ, chloroquine; DMV, double-membrane vesicle; GI, gastrointestinal; HCQ, hydroxychloroquine; IL, interleukin; MAP1LC3/LC3, microtubule associated protein 1 light chain 3; MEFs, mouse embryonic fibroblasts; MERS-CoV, Middle East respiratory syndrome coronavirus; MHV, murine hepatitis virus; PE, phosphatidylethanolamine; SARS-CoV, severe acute respiratory syndrome coronavirus; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2; TMPRSS2, transmembrane serine protease 2; TNF, tumor necrosis factor; WHO, World Health Organization.
Topics & Concepts
BiologyAutophagyCoronavirus disease 2019 (COVID-19)PandemicSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)2019-20 coronavirus outbreakVirologyBetacoronavirusDiseaseSars virusImmunologyInfectious disease (medical specialty)GeneticsOutbreakMedicineApoptosisPathologyAutophagy in Disease and TherapyExtracellular vesicles in diseaseCalcium signaling and nucleotide metabolism