Phage-Antibiotic Cocktail Rescues Daptomycin and Phage Susceptibility against Daptomycin-Nonsusceptible Enterococcus faecium in a Simulated Endocardial Vegetation <i>Ex Vivo</i> Model
Ashlan J. Kunz Coyne, Kyle Stamper, Amer El Ghali, Razieh Kebriaei, Biswajit Biswas, Melanie Wilson, Michael V. Deschenes, Truc T. Tran, César A. Arias, Michael J. Rybak
Abstract
Our study supports the additional benefit of standard-of-care antibiotics combined with a phage cocktail compared to antibiotic alone against a daptomycin-nonsusceptible (DNS) E. faecium isolate in a high-inoculum simulated endocardial vegetation ex vivo PK/PD model. E. faecium is a leading cause of hospital-acquired infections and is associated with significant morbidity and mortality. Daptomycin is considered the first-line therapy for vancomycin-resistant E. faecium (VRE), but the highest published doses have failed to eradicate some VRE isolates.
Topics & Concepts
DaptomycinEnterococcus faeciumAntibioticsMicrobiologyEx vivoEnterococcusVancomycinBiologyIn vivoMedicineBacteriaStaphylococcus aureusBiotechnologyGeneticsAntimicrobial Resistance in StaphylococcusBacteriophages and microbial interactionsBacterial Identification and Susceptibility Testing