Experimentally Engineered Mutations in a Ubiquitin Hydrolase, UBP-1, Modulate <i>In Vivo</i> Susceptibility to Artemisinin and Chloroquine in Plasmodium berghei
Nelson V. Simwela, Katie R. Hughes, A. Roberts, Michael T. Rennie, Michael P. Barrett, Andrew P. Waters
Abstract
As resistance to artemisinins (current frontline drugs in malaria treatment) emerges in Southeast Asia, there is an urgent need to identify the genetic determinants and understand the molecular mechanisms underpinning such resistance. Such insights could lead to prospective interventions to contain resistance and prevent the eventual spread to other regions where malaria is endemic. Reduced susceptibility to artemisinin in Southeast Asia has been primarily linked to mutations in the Plasmodium falciparum Kelch-13 gene, which is currently widely recognized as a molecular marker of artemisinin resistance.
Topics & Concepts
ArtemisininPlasmodium falciparumPlasmodium bergheiMalariaChloroquineDrug resistanceBiologySoutheast asiaPlasmodium (life cycle)VirologyGeneticsImmunologyParasite hostingAncient historyHistoryWorld Wide WebComputer scienceMalaria Research and ControlHIV/AIDS drug development and treatmentHIV Research and Treatment