Mn–DNA coordination of nanoparticles for efficient chemodynamic therapy
Li Lin, Jiantao Yu, Hongwei Lu, Zixiang Wei, Zhicong Chao, Zhongling Wang, WU Weitao, Hengfeng Jiang, Leilei Tian
Abstract
A kind of nanoparticle is developed for highly efficient chemodynamic therapy that only relies on the endogenous H2O2 of cancer cells. For this nanoparticle, high-molecular-weight DNA is used as the biocompatible carrier to load abundant Mn2+ ions. Therefore, the resultant Mn-DNA coordination nanoparticles can efficiently deliver and sensitively release Mn2+ in cancer cells, resulting in high toxicity through the Fenton-like reaction.
Topics & Concepts
DNAChemistryCancer therapyManganeseIonApoptosisCombinatorial chemistryNanoparticleBiophysicsCancer researchCancerBiochemistryNanotechnologyBiologyMaterials scienceOrganic chemistryGeneticsAdvanced biosensing and bioanalysis techniquesNanoplatforms for cancer theranosticsAdvanced Nanomaterials in Catalysis