Short-term physical inactivity induces diacylglycerol accumulation and insulin resistance in muscle via lipin1 activation
Saori Kakehi, Yoshifumi Tamura, Shin‐ichi Ikeda, Naoko Kaga, Hikari Taka, Noriko Ueno, Tetsuya Shiuchi, Atsushi Kubota, Keishoku Sakuraba, Ryuzo Kawamori, Hirotaka Watada
Abstract
Physical inactivity impairs muscle insulin sensitivity. However, its mechanism is unclear. To model physical inactivity, we applied 24-h hind-limb cast immobilization to mice with normal or high-fat diet and evaluated intramyocellular lipids and the insulin signaling pathway in the soleus muscle. We found that even short-term immobilization increases intramyocellular diacylglycerol and impairs insulin sensitivity in muscle via enhanced lipin1 activity.
Topics & Concepts
Diacylglycerol kinaseInternal medicineEndocrinologyInsulin resistanceInsulinInsulin receptorSkeletal muscleGlucose uptakePhosphorylationChemistryProtein kinase CBiologyBiochemistryMedicineAdipose Tissue and MetabolismLipid metabolism and biosynthesisMuscle metabolism and nutrition