HDL-C and apolipoprotein A-I are independently associated with skeletal muscle mitochondrial function in healthy humans
John M. Giacona, Ursa Bezan Petric, Weerapat Kositanurit, Jijia Wang, Suzanne Saldanha, Benjamin E. Young, Ghazi Khan, Margery A. Connelly, Scott A. Smith, Anand Rohatgi, Wanpen Vongpatanasin
Abstract
Our study provides the first direct evidence supporting the beneficial role of HDL-C and ApoA-I on enhanced skeletal muscle mitochondrial function in healthy young to middle-aged humans without cardiometabolic disease.
Topics & Concepts
Internal medicineEndocrinologySkeletal muscleApolipoprotein BCholesterolHigh-density lipoproteinLipoproteinApolipoprotein A1Body mass indexMitochondrionBiologyChemistryMedicineBiochemistryAdipose Tissue and MetabolismDiabetes, Cardiovascular Risks, and LipoproteinsNutrition and Health in Aging