Benzylic C–H isocyanation/amine coupling sequence enabling high-throughput synthesis of pharmaceutically relevant ureas
Sung‐Eun Suh, Leah E. Nkulu, Shishi Lin, Shane W. Krska, Shannon S. Stahl
Abstract
-fluorobenzenesulfonimide]. The isocyanate products may be used without isolation or purification in a subsequent coupling step with primary and secondary amines to afford hundreds of diverse ureas. These results provide a template for implementation of C-H functionalization/cross-coupling in drug discovery.
Topics & Concepts
SelectivityCombinatorial chemistryReagentCatalysisCoupling (piping)Amine gas treatingThroughputChemistrySequence (biology)Organic chemistryMaterials scienceComputer scienceWirelessBiochemistryMetallurgyTelecommunicationsCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsCyclopropane Reaction Mechanisms