Nanotherapeutic approaches for delivery of long non-coding RNAs: an updated review with emphasis on cancer
Fatemeh Davodabadi, Shekoufeh Mirinejad, Sumira Malik, Archna Dhasmana, Fulden Ulucan‐Karnak, Sara Sargazi, Sara Sargazi, Saman Sargazi, Saman Sargazi, Sonia Fathi‐karkan, Abbas Rahdar
Abstract
. The developed nanocarriers can protect, target, and release lncRNAs under controlled conditions without appreciable adverse effects. To deliver lncRNAs to cancer cells, various nanocarriers, such as exosomes, microbubbles, polymer nanoparticles, 1,2-dioleyl-3-trimethylammoniumpropane chloride nanocarriers, and virus-like particles, have been successfully developed. Despite this, every nanocarrier has its own advantages and disadvantages when it comes to delivering nucleic acids effectively and safely. This article examines the current status of nanocarriers for lncRNA delivery in cancer therapy, focusing on their potential to enhance cancer treatment.