A nucleic acid nanogel dually bears siRNA and CpG motifs for synergistic tumor immunotherapy
Qiushuang Zhang, Yuanyuan Guo, Lijuan Zhu, Xinlong Liu, Jiapei Yang, Yuehua Li, Xinyuan Zhu, Chuan Zhang
Abstract
T cell infiltration, and thus successfully restrain tumor growth. Our study demonstrates the new potential of a nucleic acid nanogel platform for the co-delivery of different therapeutic oligonucleotides and combinatorial CpG-based immunotherapy.
Topics & Concepts
Nucleic acidNanogelCpG siteChemistryCpG OligodeoxynucleotideImmunotherapyCell biologyMolecular biologyCancer researchBiochemistryBiologyGene expressionGeneImmunologyImmune systemDrug deliveryDNA methylationOrganic chemistryRNA Interference and Gene DeliveryImmune cells in cancerNanoplatforms for cancer theranostics