Zeolite-Loaded Hydrogels as Wound pH-Modulating Dressings for Diabetic Wound Healing
Léo‐Paul Tricou, Natalie Guirguis, Katia Cherifi, Simon Matoori
Abstract
Wound pH has emerged as a promising therapeutic target in diabetic foot ulcers (DFU). Here, we aimed to develop a microparticle-loaded hydrogel for pH modulation in wound fluid. In a screen of polymeric and inorganic microparticles, zeolites were identified as pH-modulating microparticles. Zeolites were encapsulated in a calcium cross-linked alginate hydrogel, a biocompatible matrix clinically used as a wound dressing. This hydrogel potently neutralized hydroxide ions in serum-containing simulated wound fluid. These findings encourage a further development of this pH-modulating device as a molecular therapeutic system for DFUs.
Topics & Concepts
Wound healingSelf-healing hydrogelsWound dressingChemistryBiomedical engineeringMedicineSurgeryMaterials sciencePolymer chemistryComposite materialWound Healing and TreatmentsHydrogels: synthesis, properties, applicationsDiabetic Foot Ulcer Assessment and Management