One-Pot Three-Component Synthesis of Indolyl-4<i>H</i>-chromene-3-sulfonyl Fluoride: A Class of Important Pharmacophore
Cheng-Lin Yin, Richard Zijian Qin, Hua‐Li Qin
Abstract
A one-pot, sequential three-component reaction between salicylaldehyde, indole, and 2-bromoprop-2-ene-1-sulfonyl fluoride (BPESF) has been demonstrated for the synthesis of sulfonyl fluoride substituted 4 H -chromene derivatives in moderate to excellent yields (45%–94%). This one-pot sequential method features easily available starting materials, wide substrate scope, mild conditions, and great efficiency.
Topics & Concepts
SulfonylSalicylaldehydeFluorideIndole testChemistryPharmacophoreComponent (thermodynamics)Combinatorial chemistrySubstrate (aquarium)Organic chemistryPolymer chemistryStereochemistryInorganic chemistrySchiff basePhysicsGeologyAlkylThermodynamicsOceanographyMulticomponent Synthesis of HeterocyclesSulfur-Based Synthesis TechniquesSynthesis of Indole Derivatives