Recombinant human klotho protects against hydrogen peroxide-mediated injury in human retinal pigment epithelial cells via the PI3K/Akt-Nrf2/HO-1 signaling pathway
Xuewei Wen, Song Li, Yanfei Zhang, Liang Zhu, Xiaoting Xi, Shuyuan Zhang, Yan Li
Abstract
-treated ARPE-19 cells. This indicates that Klotho protects cells from oxidative stress by activating phosphatidylinositol 3 kinase (PI3K)/protein kinase B (Akt)-nuclear factor E2-related factor 2 (Nrf2)/heme oxygenase 1 (HO-1) signaling pathway. Klotho is, therefore, a potential preventive or treatment option for AMD.
Topics & Concepts
Protein kinase BOxidative stressReactive oxygen speciesSuperoxide dismutaseChemistryCell biologyPI3K/AKT/mTOR pathwaySOD2KlothoCatalaseRetinal pigment epitheliumSignal transductionBiologyBiochemistryRetinalEndocrinologyKidneyRetinal Diseases and TreatmentsBiomedical Research and PathophysiologyHeme Oxygenase-1 and Carbon Monoxide