Mechanistic Studies of the Palladium-Catalyzed Desulfinative Cross-Coupling of Aryl Bromides and (Hetero)Aryl Sulfinate Salts
Antoine de Gombert, Alasdair I. McKay, Christopher J. Davis, Katherine M. P. Wheelhouse, Michael C. Willis
Abstract
to a catalytically active Pd(0) complex. Together, these studies shed light on the challenges that must be overcome to deliver improved, lower temperature versions of these synthetically important processes.
Topics & Concepts
TransmetalationChemistryArylPyridineReagentOxidative additionPalladiumBromideCombinatorial chemistryCatalysisNucleophileCoupling reactionMedicinal chemistryOrganic chemistryAlkylCatalytic Cross-Coupling ReactionsSulfur-Based Synthesis TechniquesCatalytic C–H Functionalization Methods