Identification of new potent anticancer derivatives through simplifying the core structure and modification on their 14- hydroxyl group from oridonin
Junkai Liu, Shaowen Xie, Xiao Shao, Songtao Xue, Pian Du, Hongyu Wu, Shengtao Xu, Zhe‐Sheng Chen, Dong‐Hua Yang, Jinyi Xu, Hong Yao
Topics & Concepts
ChemistryK562 cellsIn vivoPharmacologyApoptosisStereochemistryPotencyNatural productIC50Structure–activity relationshipIn vitroCell cycle checkpointCell cycleCombinatorial chemistryBiochemistryBiologyBiotechnologyMedicineBioactive Natural Diterpenoids ResearchPlant-based Medicinal ResearchBerberine and alkaloids research