Litcius/Paper detail

Identification of new potent anticancer derivatives through simplifying the core structure and modification on their 14- hydroxyl group from oridonin

Junkai Liu, Shaowen Xie, Xiao Shao, Songtao Xue, Pian Du, Hongyu Wu, Shengtao Xu, Zhe‐Sheng Chen, Dong‐Hua Yang, Jinyi Xu, Hong Yao

2022European Journal of Medicinal Chemistry20 citationsDOI

Topics & Concepts

ChemistryK562 cellsIn vivoPharmacologyApoptosisStereochemistryPotencyNatural productIC50Structure–activity relationshipIn vitroCell cycle checkpointCell cycleCombinatorial chemistryBiochemistryBiologyBiotechnologyMedicineBioactive Natural Diterpenoids ResearchPlant-based Medicinal ResearchBerberine and alkaloids research