Diastereoselective Pd-Catalyzed Anomeric C(sp<sup>3</sup>)–H Activation: Synthesis of α-(Hetero)aryl C-Glycosides
Juba Ghouilem, Christine Tran, Nicolás Grimblat, Pascal Retailleau, Mouâd Alami, Vincent Gandon, Samir Messaoudi
Abstract
Anomeric C–H bond activation is an unsolved long-standing synthetic challenge. Herein, we report a diastereoselective Pd-catalyzed anomeric C(sp3)–H activation methodology that allows the synthesis of elusive C-(hetero)aryl glycosides with an exclusive α-selectivity.
Topics & Concepts
AnomerCatalysisArylChemistryGlycosideSelectivityStereochemistryCombinatorial chemistryOrganic chemistryAlkylCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsCyclopropane Reaction Mechanisms